The Development of Decision-making Tool for Chemical Management Based on Risk Analysis: A Pilot Study
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In recent years, several incidents of improper use of chemical substances have occurred in Taiwan, causing harm to the environment and the public. In order to more effectively control the source, in 2016, the Toxic and Chemical Substances Bureau of the Environmental Protection Administration of the Executive Yuan was established to strengthen the control, management and supervision of hazardous chemicals for the safeguard of people's health.
This project consolidates the classification and assessment frameworks of chemical substances in the European Union, the United States and Canada to discuss the risk-assessment-based classification methods of chemical substances, specifically focusing on their regulatory framework, evaluation and screening process, and use of tools and selection criteria. In addition, the current international trend of advancements in the process of chemical screening are also discussed. The management and evaluation of chemical substances has gradually begun to transform from evaluating single substances to a grouping approach where chemical substances are first classified into groups with similar characteristics, and then evaluating the same class of substances at the same time. Among the many classification schemes, classification based on the chemical’s mode of action is gradually being emphasized, not only for carcinogens, but also non-carcinogenic effects, endocrine effects and ecological assessments.
The risk assessment process relies heavily on relevant toxicological information, especially in the steps of hazard identification and dose-response assessment, which make use of data collected from animal experiments. Research has begun to establish methods for data quality assessments and the use of non-experimental toxicological data, including high-throughput screening, computational toxicology, in-silico methods, and integrated testing strategy in risk assessment in hope to replace traditional in-vitro and in-vivo approach.
Based on current international trends of
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Keyword |
Risk Assessment、Concerned Chemical Substances、Decision-making benchmarks
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